What Melatonin Does To Your DNA

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Spoiler: it’s good

What dreams may come, when we have shuffled off this deoxyribonucleic coil,

…must indeed give us pause!

Researchers (Dr. Umaimah Zanif et al.) did a randomized, placebo-controlled trial of 40 night-shift workers tested whether taking 3mg of melatonin daily for 4 weeks before daytime sleep (because: night-shift workers) could improve the body’s ability to repair oxidative DNA damage.

Why Dr. Zanif and her team investigated melatonin: melatonin normally rises at night and helps regulate sleep and circadian rhythms, but overnight work suppresses melatonin production, which can reduce the body’s capacity to repair oxidative DNA damage, and could be one mechanism linking long-term night-shift work to a higher cancer risk.

Quick note about the participants: all workers had performed at least two consecutive night shifts per week for at least 6 months, with shifts lasting at least 7 hours, and none had sleep disorders or major chronic illnesses.

Of course, that’s not to say it’s only night workers who are affected—it’s relevant for anyone with disrupted sleep. But night workers make for a clear, consistent demographic in which to study these matters.

You may be wondering how DNA repair was measured: the team measured urinary 8-hydroxy-2′-deoxyguanosine (8-OH-dG), a marker of oxidative DNA damage repair capacity, with higher levels interpreted as greater DNA repair activity.

The results, in numbers:

  • Main finding: during daytime sleep after night-shift work, the melatonin group showed approximately 1.8 times higher urinary 8-OH-dG levels than the placebo group, suggesting improved oxidative DNA repair capacity.
  • Statistical analysis: the increase was described as borderline statistically significant, with a 95% confidence interval of 1.0 to 3.2 and a p-value of 0.06.
  • One more thing: no significant difference between groups was observed during the subsequent overnight work period, suggesting the benefit occurred specifically during sleep rather than throughout the entire day.

In other words, restoring melatonin signaling can counter some of the biological stress caused by circadian disruption in general and night work as a top-tier example of that.

You can read the paper in full, here: Melatonin supplementation and oxidative DNA damage repair capacity among night shift workers: a randomised placebo-controlled trial

We’ve also written a bit about melatonin before, including:

Want more options?

Some sleep aids can help, but many are harmful and/or do not really work as such; here’s a rundown of examples of those: Safe Effective Sleep Aids For Seniors?

Want to learn more?

For a much more in-depth treatment of the topic of sleep in general, you might like this book that we reviewed a while back:

Why We Sleep – by Dr Matthew Walker

Basically, if you will read only one book on sleep, that’s the book.

Sweet dreams!

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  • Should I break up with my GP? 4 signs it may be time

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    A long-term relationship with a GP – one who knows you and your history – improves your health and even reduces your chance of dying prematurely.

    This type of trusted relationship is particularly important if you have a serious or chronic (long-term) condition or multiple conditions. It is also important for trauma survivors, who should not need to retell their story over and over.

    However, there are times when you may feel uncomfortable with your current GP. The first step is understanding why, then knowing what to do about it. Here are some reasons you might consider finding another one.

    sturti/Getty

    1. Your needs have changed

    It is common to change GPs at pivotal times in your life. You may feel uncomfortable discussing your sexual health needs with the “family GP” who has known you since you were a child, or who still sees your parents.

    If your family is having children, you may prefer a GP who does antenatal care, or sees a lot of children, so they can more readily empathise with your needs as a young parent. Perhaps your current GP doesn’t share your ideas about health care and parenting, or the practice isn’t particularly child friendly.

    You may have appreciated your GP’s practical, straightforward and efficient consultation style for past sports injuries, but find this approach unhelpful when struggling with your mental health.

    So you may look for a GP who better meets your current needs.

    2. You want another GP who is expert in your illness

    Good GPs can get “up to speed” on a variety of conditions, while still keeping the whole person in view. But sometimes, you will have a very specific need that leads to seeking a GP who is expert in that area. An example may be a GP who specialises in skin checks, or a GP who is expert in ADHD (attention deficit hyperactivity disorder).

    However, you still need a generalist GP who looks at your other health-care needs. This generalist GP may well be the one who picks up early Parkinson’s disease or bowel cancer while your other GP is focused on your reproductive system or mental health.

    3. You want a GP who is more aligned with your values

    People differ in the type of relationship they want with their GP. You might be seeking a true partnership, where you both bring your expertise into decision making and you have the final decision. At the other end of the spectrum, you may feel more comfortable with your GP taking a more assertive role. Your needs and preferences may change over time.

    Sometimes, your GP doesn’t seem to accept your views on health care. You might feel uncomfortable discussing the role of complementary medicine, or preventive health care, or your decisions to accept or reject certain treatments.

    So you may seek a GP who is more aligned with your attitudes and practices.

    However, GPs have their limits when it comes to accommodating your preferences. They cannot always supply your preferred medication, referral or other service, for professional, regulatory, legal or other reasons.

    4. There has been a fracture of trust or confidence

    Everyone makes mistakes. Sometimes, those mistakes are so serious you cannot go back to that doctor. However, there are errors where the relationship can be repaired.

    A good GP will explain why an error happened, show how they (and the practice) will rectify the error, and what systems are now in place to make sure it doesn’t happen again. A sincere apology and equally sincere desire to make things right can strengthen a relationship and restore trust.

    Sometimes you can feel unheard during a consultation, or the GP can seem distracted. The GP may sincerely apologise, and explain why. They are human, and can be unwell, exhausted by an untenable workload, or simply recovering from a particularly challenging consultation earlier in the day.

    However, if there is a pattern of feeling the GP doesn’t hear you, makes frequent minor errors, or simply doesn’t seem to be providing the sort of professional service you expect, you may lose trust. If you feel uneasy or judged, you may need to step away from that GP.

    How to break up with your GP

    Good GPs understand a partnership with you is important. If you cannot maintain a relationship with them that is open, honest and safe, it is time to move on.

    If your needs have changed, but you still value the GP for their care, you can send a thank you card and explain you have chosen to transfer to another doctor. The practice staff can forward your records to a new practice, for which there may be a small administrative fee.

    If there has been a rupture in trust or confidence, and the issue is relatively minor, the practice manager will be able to advise how to make a written complaint to the practice.

    If the problem is more serious, and you wish to make a formal complaint about a breach of trust that has implications for patient safety, you can report this to the Australian Health Practitioner Regulation Agency.

    If the problem is about the GP practice, you can report it to the relevant health-care ombudsman or commission in your state or territory.

    Louise Stone, Professor of General Practice, University of Adelaide

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • The Off-Button For Your Brain

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    The Off-Button For Your Brain

    We evolved our emotions for our own benefit as a species. Even the “negative” ones:

    • Stress keeps us safe by making sure we take important situations seriously
    • Anger keeps us safe by protecting us from threats
    • Disgust keeps us safe by helping us to avoid things that might cause disease
    • Anxiety keeps us safe by ensuring we don’t get complacent
    • Guilt keeps us safe by ensuring we can function as a community
    • Sadness keeps us safe by ensuring we value things that are important to us, and learn to become averse to losing them
    • …and so on

    But that’s not always useful. What was once a very good response to a common source of fear (for example, a sabre-toothed tiger) is no longer a helpful response to a modern source of fear (for example, an important interview).

    Sometimes it’s good to take the time and energy to process our feelings and the event(s) that prompted those feelings. Sometimes, we don’t have that luxury.

    For example, if you are stressed about your workload? Then staying awake half the night thinking about it is only going to make your problems worse the next day.

    So, how to switch that off, or at least put a pause on it?

    The human mind tends to have a “negative bias”, evolved for our own protection. If something is “good enough”, we don’t need to worry about it, so we move on to the next thing, until we find something that is a problem, then we dwell on that. That’s not always helpful, and the good news is, there’s a way to flip the switch on this process:

    Identifying the positive, and releasing the rest

    This exercise can be done when you’re trying to sleep, or at any time you need a calmer, quieter mind.

    Take a moment to notice whatever you’re experiencing.

    If it’s something that feels good, or neutral, identify it with a single word. For example:

    • Warmth
    • Soft
    • Security
    • Smile
    • Peace

    If it’s something that feels bad, then instead of identifying it, simply say (or think) to yourself “release”.

    You can’t fight bad feelings with force, and you can’t “just not think about them”, but you can dismiss them as soon as they arrive and move onto the next thing. So where your train of thought may previously have been:

    It’s good to be in bed ➔ I have eight hours to sleep before my meeting ➔ Have I done everything I was supposed to? ➔ I hope that what I’ve done is good enough ➔ [Mentally rehearsing how the meeting might go] ➔ [various disaster preparations] ➔ What am I even going to wear? ➔ Ugh I forgot to do the laundry ➔ That reminds the electricity bill is due ➔ Etc

    Now your train of thought may be more like:

    Relief ➔ Rest ➔ But my meeti—release ➔ If I—release ➔ soft ➔ comfort ➔ release ➔ pillow ➔ smile ➔ release ➔ [and before you know it you’re asleep]

    And if you do this in a situation where you’re not going to sleep? Same process, just a more wakeful result, for example, let’s move the scene to an office where your meeting will shortly take place:

    Five minutes to go ➔ What a day ➔ Ok, I’d better clear my head a bit ➔ release ➔ release ➔ breath ➔ light ➔ chair ➔ what if—release ➔ prepared ➔ ready ➔ calm ➔ [and before you know it you’re impressing your work associate with your calm preparedness]

    In summary:

    If you need to stop a train of thought, this method may help. Especially if you’re in a situation where you can’t use some external distraction to keep you from thinking about the bad thing!

    You’re probably still going to have to deal with the Bad Thing™ at some point—you’ve just recognized that now isn’t the time for that. Mentally postpone that so that you will be well-rested when you choose to deal with the Bad Thing™ later at your convenience.

    So remember: identify the positive (with a single word), and anything else, just release.

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  • Mango vs Guava – Which is Healthier?

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    Our Verdict

    When comparing mango to guava, we picked the guava.

    Why?

    Looking at macros first, these two fruits are about equal on carbs (nominally mango has more, but it’s by a truly tiny margin), while guava has more than 3x the protein and more than 3x the fiber. A clear win for guava.

    In terms of vitamins, mango has more of vitamins A, E, and K, while guava has more of vitamins B1, B2, B3, B5, B7, B9, and C. Another win for guava.

    In the category of minerals, mango is not higher in any minerals, while guava is higher in calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc.

    In short, enjoy both; both are healthy. But if you’re choosing one, there’s a clear winner here, and it’s guava.

    Want to learn more?

    You might like to read:

    What’s Your Plant Diversity Score?

    Take care!

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  • Sweet Dreams Are Made of THC (Or Are They?)

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    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝I’m one of those older folks that have a hard time getting 7 hrs. I know a lot of it my fault…like a few beers at nite…🥰am now trying THC gummies for anxiety, instead of alcohol……less calories 😁how does THC affect our sleep,? Safer than alcohol…..I know your next article 😊😊😊😊❣️😊alot of us older kids do take gummies 😲😲😲thank you❞

    Great question! We wrote a little about CBD gummies (not THC) before:

    Do CBD Gummies Work?

    …and went on to explore THC’s health benefits and risks here:

    Cannabis Myths vs Reality

    For starters, let’s go ahead and say: you’re right that it’s safer (for most people) than alcohol—but that’s not a strong claim, because alcohol is very bad for pretty much everything, including sleep.

    So how does THC measure up when it comes to sleep quality?

    Good news: it affects the architecture of sleep in such a way that you will spend longer in deep sleep (delta wave activity), which means you get more restorative and restful sleep!

    See also: Alpha, beta, theta: what are brain states and brain waves? And can we control them?

    Bad news: it does so at the cost of reducing your REM sleep, which is also necessary for good brain health, and will cause cognitive impairment if you skip too much. Normally, if you are sleep-deprived, the brain will prioritize REM sleep at the cost of other kinds of sleep; it’s that important. However, if you are chemically impaired from getting healthy REM sleep, there’s not much your brain can do to save you from the effects of REM sleep loss.

    See: Cannabis, Cannabinoids, and Sleep: a Review of the Literature

    This is, by the way, a reason that THC gets prescribed for some sleep disorders, in cases where the initial sleep disruption was because of nightmares, as it will reduce those (along with any other dreams, as collateral damage):

    Clinical Management of Sleep and Sleep Disorders With Cannabis and Cannabinoids: Implications to Practicing Psychiatrists

    One thing to be careful of if using THC as a sleep aid is that withdrawal may make your symptoms worse than they were to start with:

    Updates in the use of cannabis for insomnia

    With all that in mind, you might consider (if you haven’t already tried it) seeing whether CBD alone improves your sleep, as while it does also extend time in deep sleep, it doesn’t reduce REM nearly as much as THC does:

    The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical trial

    👆 this study was paid for by the brand being tested, so do be aware of potential publication bias. That’s not to say the study is necessarily corrupt, and indeed it probably wasn’t, but rather, the publication of the results was dependent on the company paying for them (so hypothetically they could have pulled funding from any number of other research groups that didn’t get the results they wanted, leaving this one to be the only one published). That being said, the study is interesting, which is why we’ve linked it, and it’s a good jumping-off-point for finding a lot of related papers, which you can see listed beneath it.

    CBD also has other benefits of its own, even without THC:

    CBD Oil: What Does The Science Say?

    Take care!

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  • Blackberries vs Grapes – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing blackberries to grapes, we picked the blackberries.

    Why?

    It’s not even close:

    In terms of macros, blackberries have more than 5x the fiber, for about half the carbs, resulting in a notably lower glycemic index. They also have more than 2x the protein, but unlike the fiber, it’s not much in either fruit, so we might disregard it. Still, an easy win for blackberries either way.

    In the category of vitamins, blackberries have more of vitamins A, B3, B5, B9, C, E, and K, while grapes have more of vitamins B1, B2, and B6. Another clear win for blackberries.

    When it comes to minerals, blackberries have a lot more calcium, copper, iron, magnesium, phosphorus, selenium, and zinc, while grapes have slightly more manganese and potassium. Once again, blackberries emerge victorious.

    In other considerations, both have an abundance of many polyphenols, but blackberries have more, both in types and in total mass (mg/100g).

    Thus, blackberries overwhelmingly win the day, but by all means enjoy either or both; diversity is best!

    Want to learn more?

    You might like:

    Can We Drink To Good Health? ← while there are polyphenols such as resveratrol in red wine that per se would boost heart health, there’s so little per glass that you may need 100–1000 glasses per day to get the dosage that provides benefits in mouse studies.

    If you’re not a mouse, you might even need more than that!

    To this end, many people prefer resveratrol supplementation ← link is to an example product on Amazon, but there are plenty more so feel free to shop around 😎

    Enjoy!

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  • Power Vegan Meals – by Maya Sozer

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    This book has inspired some of the recipes we’ve shared recently—we’ve invariably tweaked and in our opinion improved them, but the recipes are great as written too.

    The recipes, of which there are 75, are all vegan, gluten-free, high protein, and high fiber. Some reviewers on Amazon have complained that the recipes are high-calorie, and they often are, but those calories are mostly from healthy fats, so we don’t think it’s a bad thing. Still, if you’re doing a strict calorie-controlled diet, this is probably not the one for you.

    Another thing the recipes are is tasty without being unduly complicated, as well as being mostly free from obscure ingredients. This latter is a good thing not because obscure ingredients are inherently bad, but rather that it can be frustrating to read a recipe and find its star ingredient is a cup of perambulatory periannath that must be harvested from the west-facing slopes of Ithilien during a full moon, no substitutions.

    The style and format is simple and clear with minimal overture, one recipe per double-page; picture on one side, recipe on the other; perfect for a kitchen reading-stand.

    Bottom line: these recipes are for the most part very consistent with what we share here, and we recommend them, unless you’re looking for low-calorie options.

    Click here to check out Power Vegan Meals, and power-up your vegan meals!

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