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A sticker showcasing the words "inverse vaccines" representing an innovative approach towards autoimmune diseases.

Inverse Vaccines for Autoimmune Diseases

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Inverse Vaccines for Autoimmune Diseases

This is Dr. Jeffrey Hubbell. He’s a molecular engineer, with a focus on immunotherapy, immune response, autoimmune diseases, and growth factor variants.

He’s held 88 patents, and was the recipient of the Society for Biomaterials’ Founders Award for his “long-term, landmark contributions to the discipline of biomaterials”, amongst other awards and honours that would make our article too long if we included them all.

And, his latest research has been about developing…

Inverse Vaccines

You may be thinking: “you mean diseases; he’s engineering diseases?”

And no, it’s not that. Here’s how it works:

Normally in the case of vaccine, it’s something to tell the body “hey, if you see something that looks like this, you should kill it on sight” and the body goes “ok, preparing countermeasures according to these specifications; thanks for the heads-up”

In the case of an inverse vaccine, it’s the inverse. It’s something to tell the body “hey, this thing you seem to think is a threat, it’s actually not, and you should leave it alone”.

Why this matters for people with autoimmune diseases

Normally, autoimmune diseases are treated in one or more of the following ways:

  • Dampen the entire immune system (bad for immunity against actual diseases, obviously, and is part of why many immunocompromised people have suffered and died disproportionately from COVID, for example)
  • Give up and find a workaround (a good example of this is Type 1 Diabetes, and just giving up on the pancreas not being constantly at war with itself, and living on exogenous insulin instead)

Neither of those are great.

What inverse vaccines do is offer a way to flag the attacked-in-error items as acceptable things to have in the body. Those might be things that are in our body by default, as in the case of many autoimmune diseases, or they may even be external items that should be allowed but aren’t, as in the case of gluten, in the context of Celiac disease.

The latest research is not yet accessible for free, alas, but you can read the abstract here:

Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses

Or if you prefer a more accessible pop-science approach, here’s a great explanatory article:

“Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

Where can we get such inverse vaccines?

❝There are no clinically approved inverse vaccines yet, but we’re incredibly excited about moving this technology forward❞

~ Dr. Jeffrey Hubbell

But! Lest you be disappointed, you can get in line already, in the case of the Celiac disease inverse vaccine, if you’d like to be part of their clinical trial:

Click here to see if you are eligible to be part of their clinical trial

If you’re not up for that, or if your autoimmune disease is something else (most of the rest of their research is presently focusing on Multiple Sclerosis and Type 1 Diabetes), then:

  • The phase 1 MS trial is currently active, estimated completion in summer 2024.
  • They are in the process of submitting an investigational new drug (IND) application for Type 1 Diabetes
    • This is the first step to starting clinical safety and efficacy trials

…so, watch this space!

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