Chromium Picolinate For Blood Sugar Control & Weight Loss

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First, a quick disambiguation:

  • chromium found in food, trivalent chromium of various kinds, is safe (in the quantities usually consumed) and is sometimes considered an essential mineral, sometimes considered unnecessary but beneficial. It’s hard to know for sure, since it’s in a lot of foods (naturally, like many trace elements)
  • chromium found in pollution, hexavalent chromium (so: twice as many cationic bonds, if this writer’s chemistry serves her correctly) is poisonous.

We’re going to be writing about the food kind, which is also possible to take as a supplement.

In this case, supplementing vs getting from food is quite a big difference, by the way, since (unlike for a lot of things, which are often the other way around) the bioavailability of chromium from food is very low (around 2.5%), whereas chromium picolinate, one of the most commonly-used supplement forms, boasts higher bioavailability.

Does it work for blood sugars?

Yes, it does! At least, it does in the case of people with type 2 diabetes. Rather than bombard you with many individual studies, here’s a systematic review and meta-analysis of 22 criteria-meeting randomized clinical trials that found:

❝The available evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes.

Chromium monosupplement may additionally improve triglycerides and HDL-C levels.❞

Source: Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes

Type 1 diabetes does not have anything like the same weight of evidence, and indeed, we couldn’t find a single human study. It was beneficial for mice with artificially-induced T1D, though wait no, we have an update! We found literally a single human study:

Chromium picolinate supplementation for diabetes mellitus

Literally, as in: it’s a case study of one person, and the results were a modest reduction in Hb A1c levels after 3 months of 600μg daily; the researchers concluded that ❝chromium picolinate continues to fall squarely within the scope of “alternative medicine,” with both unproven benefits and unknown risks❞.

As for people without diabetes, it may reduce the risk of diabetes:

Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements

However! This was an observational study, and correlation ≠ causation.

Furthermore, they said:

❝Over one-half the adult US population consumes nutritional supplements, and over one-quarter consumes supplemental chromium. The odds of having T2D were lower in those who, in the previous 30 d, had consumed supplements containing chromium❞

That “over one-quarter consumes supplemental chromium” brought our attention to the fact that this is not talking about specifically chromium “monosupplements” (definitely not quarter of the adult population take those), but rather, “multivitamin and mineral” supplements that also contain a tiny amount (often under 50μg) of chromium.

In other words, this ruins the data and honestly the benefit could have been from anything in the “multivitamin and mineral” supplement, or indeed, could just be “the kind of person who takes supplements is the kind of person who lives a lifestyle that is less conducive to becoming diabetic”.

Does it work for weight loss?

We’re running out of space here, so we’ll be brief:

No.

There are many papers that have concluded this, but here are two:

Chromium picolinate supplementation for overweight or obese adults

and

The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent

Is it safe?

Science’s current best answer is “we don’t know; it hasn’t been tested enough; we haven’t even established the tolerable upper limit, which is usually step 1 of establishing safety”.

Nor is there an estimated average requirement (if indeed there even is a requirement, which question is also not as yet answered conclusively by science), and science falls back to “here’s an average of what people consume in their diet, so that’s probably safe, we guess”.

(that average was reckoned as 25μg/day for young women and 25μg/day for young men, by the way; older ages not as yet reckoned)

You can read about this sorry state of affairs here.

Want to try some?

Notwithstanding the above lack of data for safety, it does have benefits for blood sugars, so if that’s a gamble you’re willing to make, then here’s an example product on Amazon.

Note: the dosage per capsule there (800μg) is half of the low end of the dose that was implicated in the serious kidney condition caused in this case study (1200–2400μg), so if you are going to try it, we strongly recommend not taking more than one per day.

Take care!

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  • The Mediterranean Diet Cookbook for Beginners – by Jessica Aledo

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    There are a lot of Mediterranean Diet books on the market, and not all of them actually stick to the Mediterranean Diet. There’s a common mistake of thinking “Well, this dish is from the Mediterranean region, so…”, but that doesn’t make, for example, bacon-laden carbonara part of the Mediterranean Diet!

    Jessica Aledo does better, and sticks unwaveringly to the Mediterranean Diet principles.

    First, she gives a broad introduction, covering:

    • The Mediterranean Diet pyramid
    • Foods to eat on the Mediterranean Diet
    • Foods to avoid on the Mediterranean Diet
    • Benefits of the Mediterranean Diet

    Then, it’s straight into the recipes, of which there are 201 (as with many recipe books, the title is a little misleading about this).

    They’re divided into sections, thus:

    • Breakfasts
    • Lunches
    • Snacks
    • Dinners
    • Desserts

    The recipes are clear and simple, one per double-page, with high quality color illustrations. They give ingredients/directions/nutrients. There’s no padding!

    Helpfully, she does include a shopping list as an appendix, which is really useful!

    Bottom line: if you’re looking to build your Mediterranean Diet repertoire, this book is an excellent choice.

    Get your copy of The Mediterranean Diet Cookbook for Beginners from Amazon today!

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  • The How Not to Die Cookbook – by Dr. Michael Greger

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    We’ve previously reviewed Dr. Greger’s “How Not To Die”, which is excellent and/but very science-dense.

    This book is different, in that the science is referenced and explained throughout, but the focus is the recipes, and how to prepare delicious healthy food in accordance with the principles laid out in How Not To Die.

    It also follows “Dr Greger’s Daily Dozen“, that is to say, the 12 specific things he advises we make sure to have every day, and thus helps us to include them in an easy, no-fuss fashion.

    The recipes themselves are by Robin Robertson, and/but with plenty of notes by Dr Greger; they clearly collaborated closely in creating them.

    The ingredients are all things one can find in any well-stocked supermarket, so unless you live in a food desert, you can make these things easily.

    And yes, the foods are delicious too.

    Bottom line: if you’re interested in cooking according to perhaps the most science-based dietary system out there, then this book is a top-tier choice.

    Click here to check out The How Not To Die Cookbook, and live well!

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  • 5 dental TikTok trends you probably shouldn’t try at home

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    TikTok is full of videos that demonstrate DIY hacks, from up-cycling tricks to cooking tips. Meanwhile, a growing number of TikTok videos offer tips to help you save money and time at the dentist. But do they deliver?

    Here are five popular dental TikTok trends and why you might treat them with caution.

    1. Home-made whitening solutions

    Many TikTok videos provide tips to whiten teeth. These include tutorials on making your own whitening toothpaste using ingredients such as hydrogen peroxide, a common household bleaching agent, and baking soda (sodium bicarbonate).

    In this video, the influencer says:

    And then you’re going to pour in your hydrogen peroxide. There’s really no measurement to this.

    But hydrogen peroxide in high doses is poisonous if swallowed, and can burn your gums, mouth and throat, and corrode your teeth.

    High doses of hydrogen peroxide may infiltrate holes or microscopic cracks in your teeth to inflame or damage the nerves and blood vessels in the teeth, which can cause pain and even nerve death. This is why dental practitioners are bound by rules when we offer whitening treatments.

    Sodium bicarbonate and hydrogen peroxide are among the components in commercially available whitening toothpastes. While these commercial products may be effective at removing surface stains, their compositions are carefully curated to keep your smile safe.

    2. Oil pulling

    Oil pulling involves swishing one tablespoon of sesame or coconut oil in your mouth for up to 20 minutes at a time. It has roots in Ayurvedic medicine, a traditional medicine practice that originates from the Indian subcontinent.

    While oil pulling should be followed by brushing and flossing, I’ve had patients who believe oil pulling is a replacement for these practices.

    There has been some research on the potential of oil pulling to treat gum disease or other diseases in the mouth. But overall, evidence that supports the effectiveness of oil pulling is of low certainty.

    For example, studies that test the effectiveness of oil pulling have been conducted on school-aged children and people with no dental problems, and often measure dental plaque growth over a few days to a couple of weeks.

    Chlorhexidine is an ingredient found in some commercially available mouthwashes.
    In one study, people who rinsed with chlorhexidine mouthwash (30 seconds twice daily) developed less plaque on their teeth compared to those who undertook oil pulling for eight to 10 minutes.

    Ultimately, it’s unlikely you will experience measurable gain to your oral health by adding oil pulling to your daily routine. If you’re time-poor, you’re better off focusing on brushing your teeth and gums well alongside flossing.

    3. Using rubber bands to fix gaps

    This TikTok influencer shows his followers he closed the gaps between his front teeth in a week using cheap clear rubber bands.

    But this person may be one of the lucky few to successfully use bands to close a gap in his teeth without any mishaps. Front teeth are slippery and taper near the gums into cone-shaped roots. This can cause bands to slide and disappear into the gums to surround the tooth roots, which can cause infections and pain.

    If this happens, you may require surgery that involves cutting your gums to remove the bands. If the bands have caused an infection, you may lose the affected teeth. So it’s best to leave this sort of work to a dental professional trained in orthodontics.

    4. Filing or cutting teeth to shape them

    My teeth hurt just watching this video.

    Cutting or filing teeth unnecessarily can expose the second, more sensitive tooth layer, called dentine, or potentially, the nerve and blood vessels inside the tooth. People undergoing this sort of procedure could experience anything from sensitive teeth through to a severe toothache that requires root canal treatment or tooth removal.

    You may notice dentist drills spray water when cutting to protect your teeth from extreme heat damage. The drill in this video is dry with no water used to cool the heat produced during cutting.

    It may also not be sterile. We like to have everything clean and sterile to prevent contaminated instruments used on one patient from potentially spreading an infection to another person.

    Importantly, once you cut or file your teeth away, it’s gone forever. Unlike bone, hair or nails, our teeth don’t have the capacity to regrow.

    5. DIY fillings

    Many people on TikTok demonstrate filling cavities (holes) or replacing gaps between teeth with a material made from heated moulded plastic beads. DIY fillings can cause a lot of issues – I’ve seen this in my clinic first hand.

    While we may make it look simple in dental surgeries, the science behind filling materials and how we make them stick to teeth to fill cavities is sophisticated.

    Filling a cavity with the kind of material made from these beads will be as effective as using sticky tape on sand. Not to mention the cavity will continue to grow bigger underneath the untreated “filled” teeth.

    I know it’s easy to say “see a dentist about that cavity” or “go to an orthodontist to fix that gap in your teeth you don’t like”, but it can be expensive to actually do these things. However if you end up requiring treatment to fix the issues caused at home, it may end up costing you much more.

    So what’s the take-home message? Stick with the funny cat and dog videos on TikTok – they’re safer for your smile.The Conversation

    Arosha Weerakoon, Senior Lecturer and General Dentist, School of Dentistry, The University of Queensland

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Gravitas – by Caroline Goyder

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    A no-nonsense guide to (more than!) public speaking that isn’t just “tell jokes in your speech and imagine the audience naked”.

    Because this isn’t just about speech-writing or speech delivery, so much as giving you important life skills. The kind that weren’t taught in school, but that nevertheless make a huge impact on success… whether you’re giving a presentation or hosting a party or negotiating a deal or just attending a social event. Or making a phonecall, even.

    Whereas a lot of books of this kind treat “the audience” as a nebulous and purely responsive passive crowd of extras, Goyder does better. People are individuals, even if they’re all facing the same way for a moment. She works with that! She also teaches how to deal with not just hecklers, but also simply those people who sap your confidence and find fault with you and anything you do or say.b

    Bottom line is: if you for whatever reason communicate with people, and would like them to think better of you, this is the book for you.

    Order your copy of Gravitas from Amazon today!

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  • Ashwagandha: The Root of All Even-Mindedness?

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    Ashwagandha: The Root Of All Even-Mindedness?

    In the past few years, Ashwagandha root has been enjoying popular use in consumer products ranging from specialist nootropic supplement stacks, to supermarket teas and hot chocolates.

    This herb is considered to have a calming effect, but the science goes a lot deeper than that. Let’s take a look!

    Last summer, a systematic review was conducted, that asked the question:

    Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress?

    While they broadly found the answer was “yes”, they expressed low confidence, and even went so far as to say there was contradictory evidence. We (10almonds) were not able to find any contradictory evidence, and their own full article had been made inaccessible to the public, so we couldn’t double-check theirs.

    We promptly did our own research review, and we found many studies this year supporting Ashwaghanda’s use for the management of anxiety and stress, amongst other benefits.

    First, know: Ashwagandha’s scientific name is “Withania somnifera”, so if you see that (or a derivative of it) mentioned in a paper or extract, it’s the same thing.

    Onto the benefits…

    A study from the same summer investigated “the efficacy of Withania somnifera supplementation on adults’ cognition and mood”, and declared that:

    “in conclusion, Ashwagandha supplementation may improve the physiological, cognitive, and psychological effects of stress.”

    We notice the legalistic “may improve”, but the data itself seems more compelling than that, because the study showed that it in fact “did improve” those things. Specifically, Ashwagandha out-performed placebo in most things they measured, and most (statistically) significantly, reduced cortisol output measurably. Cortisol, for any unfamiliar, is “the stress hormone”.

    Another study that looked into its anti-stress properties is this one:

    Ashwagandha Modulates Stress, Sleep Dynamics, and Mental Clarity

    This study showed that Ashwagandha significantly outperformed placebo in many ways, including:

    • sleep quality
    • cognitive function
    • energy, and
    • perceptions of stress management.

    Ashwagandha is popular among students, because it alleviates stress while also promising benefits to memory, attention, and thinking. So, this study on students caught our eye:

    The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial

    Their findings demonstrated that Ashwagandha increased college students’ perceived well-being through supporting sustained energy, heightened mental clarity, and enhanced sleep quality.

    That was about perceived well-being and based on self-reports, though

    So: what about hard science?

    A later study (in September) found supplementation with 400 mg of Ashwagandha improved executive function, helped sustain attention, and increased short-term/working memory.

    Read the study: Effects of Acute Ashwagandha Ingestion on Cognitive Function

    ❝But aside from the benefits regarding stress, anxiety, sleep quality, cognitive function, energy levels, attention, executive function, and memory, what has Ashwagandha ever done for us?

    Well, there have been studies investigating its worth against depression, like this one:

    Can Traditional Treatment Such as Ashwagandha Be Beneficial in Treating Depression?

    Their broad answer: Ashwagandha works against depression, but they don’t know how it works.

    They did add: “Studies also show that ashwagandha may bolster the immune system, increase stamina, fight inflammation and infection, combat tumors*, reduce stress, revive the libido, protect the liver and soothe jangled nerves.

    That’s quite a lot, including a lot of physical benefits we’ve not explored in this research review which was more about Ashwagandha’s use as a nootropic!

    We’ve been focusing on the more mainstream, well-studied benefits, but for any interested in Ashwagandha’s anti-cancer potential, here’s an example:

    Evaluating anticancer properties of [Ashwagandha Extract]-a potent phytochemical

    In summary:

    There is a huge weight of evidence (of which we’ve barely skimmed the surface here in this newsletter, but there’s only so much we can include, so we try to whittle it down to the highest quality most recent most relevant research) to indicate that Ashwagandha is effective…

    • Against stress
    • Against anxiety
    • Against depression
    • For sleep quality
    • For memory (working, short-term, and long-term)
    • For mental clarity
    • For attention
    • For stamina
    • For energy levels
    • For libido
    • For immune response
    • Against inflammation
    • Against cancer
    • And more*

    *(seriously, this is not hyperbole… We didn’t even look at its liver-protective functions, for instance)

    Bottom line:

    You’d probably like some Ashwagandha now, right? We know we would.

    We don’t sell it (or anything else, for that matter), but happily the Internet does:

    Try Out Ashwagandha For Yourself Here!

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  • Passion Fruit vs Persimmon – Which is Healthier?

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    Our Verdict

    When comparing passion fruit to persimmon, we picked the passion fruit.

    Why?

    You may be wondering: “what is this fruit passionate about?” and the answer is: delivering nutrients of many kinds!

    Looking at the macros first, passion fruit has a little more protein and a lot more fiber, while persimmon has more carbs. This means that while persimmon’s glycemic index isn’t bad, passion fruit’s glycemic index is a lot lower.

    In terms of vitamins, passion fruit has a lot more of vitamins A, B2, B3, B6, B9, E, K, and choline, while persimmon has more vitamin C. For the record passion fruit is also a good source of vitamin C, with a cup of passion fruit already giving a day’s daily dose of vitamin C, but persimmon gives twice that. Still, that’s a 8:1 win for passion fruit.

    When it comes to minerals, passion fruit has more copper, magnesium, phosphorus, potassium, selenium, and zinc, while persimmon has more calcium and iron, meaning a 6:2 win for passion fruit.

    Adding up the three convincing individual victories shows a clear overall win for passion fruit.

    Enjoy (passionately, even)!

    Want to learn more?

    You might like to read:

    Take care!

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