
The Two-Second Advantage – by Vivek Ranadive and Kevin Maney
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The titular “two-second advantage” can in some cases be literal (imagine you got a two-second head-start in a boxing match!), in other cases can refer to being just a little ahead of things in a way that can confer a great advantage, often cumulatively—as anyone who’s played Monopoly can certainly attest.
Vivek Ranadivé and Kevin Maney give us lots of examples from business, sports, politics, economics, and more, in a way that seeks to cultivate a habit of asking the right questions in order to anticipate the future and not just be ahead of the competition—some areas of life don’t have competition for most people, like health, for example—but to generally have things “in hand”.
When it comes to personal finances, health, personal projects, and the like, those tiny initial advantages that lead to incremental further improvements, can be the difference between continually (and frantically) playing catch-up, or making the jump past breaking even to going from strength to strength.
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Plant Milk vs Dairy: His & Hers?
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When it comes to osteoporosis risk, common wisdom says “get plenty of dairy”. However, there are several things to bear in mind:
- Milk is a great source of calcium, which is useless to the body if you don’t also have good levels of vitamin D and magnesium.
- People’s vitamin D levels tend to directly correlate to the level of sun where they live, if supplementation isn’t undertaken.
- Plant-based milks are usually fortified with vitamin D (and calcium), by the way.
- Most people are deficient in magnesium, because green leafy things don’t form as big a part of most people’s diets as they should.
See also: An update on magnesium and bone health
And of course, dairy has its own health risks, the relatively most well-known of which (sadly still not that well-known) is inflammation; see: How to Prevent (or Reduce) Inflammation
His & Hers
It’s interesting that some of the other health benefits/risks of dairy are contentious (i.e. mixed evidence), because in vitro modelling of sex differences in digestion of different kinds of milk (plant and animal) have found:
❝In the case of dairy milk, male gut conditions liberated various known bioactive peptides with antimicrobial, Dipeptidyl peptidase-4 inhibitor and cholesterol regulating activities.
Contrary, female gastric conditions led to the liberation of an osteoanabolic peptide. Moreover, female gut conditions were able to liberate more free amino acids from oat milk rather than from dairy milk while male conditions yielded an inverse trend.❞
Translating from sciencese:
- in the male model, cow-derived dairy milk proteins were broken down more efficiently, producing more antimicrobial peptides (that’s good, contextually)
- in the female model, oat-based plant milk proteins digested more efficiently, generating osteoanabolic peptides that are important for bone formation (that’s good in almost any context)
This becomes super-important when we note that women have, other things being equal, a much higher risk of osteoporosis than men.
You can read the paper in full here: Sex-based differences in in vitro digestibility of milk and oat drink, and powder counterparts
What about estrogen in soy milk?
That study used oat milk (which is very healthful).
However, since we’re talking plant milks and sex: many people cite the phytoestrogens in soy milk as a reason that women should drink it, and men should not. That’s half-correct:
- For women, the phytoestrogens in soy milk cannot be used as estrogen directly (not compatible with human estrogen), but it can be broken down and the parts used to make new, compatible, human estrogen (assuming you have working ovaries, to produce that estrogen).
- For men, the phytoestrogens in soy milk cannot be used as estrogen directly (not compatible with human estrogen), but it can be broken down and the parts used to make new, compatible, human testosterone (assuming you have working testes, to produce that testosterone).
This means, gentlemen-readers, that no, soy milk will not have any feminizing effect on you (unless you have ovaries instead of testes, in which case yes, it’ll boost your natural estrogen production).
See for example this research review with 439 sources of its own: Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
You may be wondering why the “ingredients” of estrogen can be used to make testosterone. It’s because on a molecular level, they’re almost identical:
❝Both estradiol and testosterone have the “steroid nucleus” and a hydroxyl group in their structures.
Apart from estradiol, testosterone has a double bond and a ketone.❞
estradiol = the main kind of estrogen that we humans use
For the more visually-inclined, you can see the molecules diagrammed next to each other here, and play spot-the-difference!
If you’d like to explore different kinds of plant milk, we examine 6 of the best, here: Which Plant Milk?
Want to learn more?
You might want to check out this well-sourced LiveStrong article:
Bone Health: Best and Worst Foods
(Teaser: leafy greens are in 2nd place, topped by sardines at #1—where do you think dairy milk ranks?)
And if you want to dive much deeper into it than we have room to here, you’ll like this book that we reviewed a little while back; it covers today’s nutritional considerations comprehensively:
Take care!
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16 Signs & Symptoms Of Kidney Disease
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Chronic kidney disease is often called a silent killer, because 90% of people don’t notice they have it until the disease has progressed to an extreme level.
While none of these signs or symptoms are guaranteed to appear, especially in the early phases, if they do show up then they are cause for getting a check-up done:
Watch out for…
These should serve as alarm bells:
- Foamy urine: persistent dense foam (like beer head) in urine suggests protein (albumin) leakage due to kidney filter damage
- Swelling (pitting edema): especially in the legs, feet, or around the eyes, caused by low blood albumin leading to fluid leakage into tissues
- Nocturia (peeing at night): frequent nighttime urination due to kidneys losing the ability to concentrate urine
- Half-and-half nails: nails with a distinct brownish band on the distal half, linked to chronic kidney disease
- Calcinosis cutis: hard white-yellow skin bumps from calcium phosphate deposits due to high blood phosphate
- Artery calcification: hardened arteries visible on X-ray caused by phosphate-induced bone-like deposits in blood vessel walls
- Muscle cramps: especially at night, due to low calcium, low magnesium, or high blood acidity from impaired kidney function
- Osteoporosis: weak, brittle bones from calcium being leached out due to disrupted calcium regulation—may cause height loss or fractures
- Itchy skin: intense, often nighttime itching caused by uremic toxins irritating nerves or accumulating in skin
- Restless legs syndrome: irresistible urge to move legs at night due to iron deficiency from chronic inflammation and hepcidin overproduction
- Metallic taste in mouth: due to urea breakdown in saliva causing ammonia and other metallic-tasting compounds
- Loss of appetite: also, potentially, nausea and vomiting triggered by toxins activating brain regions that sense food poisoning
- Easy bruising: from reduced platelet stickiness, leading to frequent unexplained bruises, gum bleeding, or nosebleeds
- Uremic frost: white crystalline powder on the skin in advanced kidney failure due to urea excreted through sweat
- Pericarditis: inflammation of the sac around the heart causing chest pain and a scratchy sound due to uremic toxins
- Fatigue (anemia): low red blood cell count from reduced erythropoietin production by kidneys, leading to extreme tiredness
Attentive readers will have noticed two things here:
- Many of these could indicate a lot of other things (e.g. fatigue can be almost anything, osteoporosis isn’t something one sees unless one checks for it, loss of appetite can be many things, etc), which helps mask kidney disease.
- Dr. Deshauer says “17 signs” in her title, so where’s the 17th? The answer is that she listed in 17th place “no symptoms”, because many people have no noticeable symptoms until the disease reaches moderate or advanced stages.
Both of those factors contribute to kidney disease’s “silent killer” status, but with good vigilance, we can stay as healthy as possible.
For more on each of these, plus some visual illustrations where appropriate, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Keeping Your Kidneys Healthy (Especially After 60) ← there’s a lot more to it than just hydration!
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What’s the difference between freckles, sunspots and moles?
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You’ve got a new brown spot on your face, but is it a freckle or a sunspot? Or perhaps you’ve found a spot on your back that looks like a mole but is flatter than your other ones – is it a mole or a dark freckle?
Here’s how to tell the difference between freckles, sunspots and moles – and when you need to get a spot checked to see if it’s skin cancer.
Cottonbro Studio/Pexels Freckles
Freckles, known as ephelides, are small, flat, light brown spots that appear on people with fair skin, or red or light-coloured hair.
These people are more likely to have the MC1R gene, which leads to freckles forming.
Freckles are caused by sun exposure and are more noticeable in summer. When sunlight hits the skin, cells called melanocytes produce melanin, the pigment that gives skin its colour.
In people prone to freckles, the melanin doesn’t spread evenly. Instead, it clumps together, creating freckles.
Melanin doesn’t spread evenly in people prone to freckles. Chermiti Mohamed/Unsplash Freckles generally appear in childhood and may fade with age, especially if sun exposure reduces. As we age we produce less melanin, or it can break down or disperse, resulting in lighter or fewer freckles.
Using sunscreen and wearing protective clothing can help prevent new freckles from developing, especially on the face and arms.
While freckles are completely harmless, they are a sign that someone is genetically at higher risk of developing skin cancer.
Sunspots
Sunspots are also called age spots or solar lentigos (or liver spots, but they have nothing to do with the liver). They are larger than freckles: sometimes the size of a small coin, and appear as flat brown spots.
Sunspots develop over time due to long-term sun exposure, which leads to excessive melanin production. They tend to appear on skin with greater sun exposure, such as the face, hands, shoulders and arms.
Sunspots develop after years of sun exposure. Zay Nyi Nyi/Shutterstock Unlike freckles, which tend to get lighter with less sun exposure, sunspots will not fade with time, and may further darken with continued sun exposure.
However, some people try to remove their sunspots for cosmetic reasons using either a laser, chemical peel or a prescription topical cream.
While sunspots are not dangerous, they do increase your risk of other skin cancers in that area.
It’s also important to monitor them, as slow-growing melanomas may initially look like sunspots. If you see the spot changes in size, shape or colour, see your doctor to rule out skin cancer.
Moles
Moles are often dark, raised or flat skin growths that can appear anywhere on your body.
Although moles can exist from birth, they typically grow during childhood, adolescence and early adulthood (including during pregnancy, when hormones are changing), until around the age of around 40. Moles can increase in size, and new ones can also appear.
Most adults have between ten and 40 moles on their body. A person with a high mole count has 50 or more, while someone with a very high mole count has 100 or more.
Some moles are raised while others are flat. Pixel-Shot/Shutterstock Moles form when melanocytes grow in clusters instead of spreading evenly throughout the skin.
Moles can either be raised or flat, depending upon their type, depth and age.
Raised moles, referred to as compound nevi, have both flat and raised portions and typically have pigment that is deeper in the skin.
Dermal nevi are skin-coloured or light brown moles that are also raised.
Most moles are harmless. Some may have hair growing from them and some may disappear, whereas other moles may darken or alter with age or hormonal changes.
However, some moles can develop into melanoma, a dangerous form of skin cancer.
When to see your doctor
While freckles and sunspots are completely harmless, moles do require more attention, especially if they change in size, shape, colour or texture.
If a mole shows any of the following warning signs, see your doctor, who will use the ABCDE rule to detect if a lesion is a skin cancer:
- asymmetry: if one half of the mole looks different from the other half
- border: if your mole is shaped irregularly, jagged or has poorly defined edges
- colour: varied shades or sudden changes in colour of the mole
- diameter: if it is larger than 6 millimeters (about the size of a pencil eraser)
- evolving: if your mole has any changes in its size, shape, colour, or sensation such as itching or bleeding for more than a few weeks.
Our research shows only 21.7% of people can correctly identify melanoma on their own, so professional checks are essential.
How to prevent skin damage
Since freckles, sunspots and some moles are influenced by exposure to the sun, you can protect your skin by:
- avoiding the sun when ultraviolet rays are strongest
- wearing sunscreen with SPF 50 every day, even when it’s cloudy. Apply it 20 minutes before going outside and reapply every two hours
- wearing protective clothing, including a wide-brimmed hat to cover your face, neck and ears, and long-sleeved shirts and pants to protect your arms and legs.
Correction: this article originally referred to sun sports as actinic keratoses rather than solar lentigos.
Mike Climstein, Associate Professor, Faculty of Health, Southern Cross University; Jeremy Hudson, Adjunct Associate Professor, Faculty of Health, Southern Cross University; Michael Stapelberg, Adjunct Associate Professor, Faculty of Health, Southern Cross University, and Nedeljka Rosic, Senior Lecturer, Faculty of Health, Southern Cross University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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How Olives Can Help Protect Your Brain
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Olives boast a special molecule that’s neuroprotective in several ways, as well as being structurally identical to dopamine metabolite:
Introducing hydroxytyrosol
Things that start with “hydroxy-” and/or end in “-ol” are often not astonishingly healthy, but this one is!
It’s approved as safe by the FDA, EFSA, and the AESAN at typical dietary levels of up to about 51 mg per day.
Hydroxytyrosol (HXT) is a phenolic compound (polyphenol, specifically a simple phenolic alcohol belonging to the family of secoiridoid-derived polyphenols found in olives and olive oil. It’s one of the key antioxidant compounds responsible for many of the health benefits associated with extra virgin olive oil.
As for its established benefits: it’s antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, antimicrobial, cardio-protective, neuroprotective, cognition-enhancing, and immune-modulatory.
Most recently, a research team from Spain (Dr. Lorena Martínez-Zamora et al.), investigated specifically its neurovascular and neuroimmune effects, in other words, how it relates to the health of the brain’s blood vessels, and the brain’s clean-up crew.
What they found:
❝HXT protects endothelial and neural cells by lowering oxidative stress, maintaining nitric oxide availability, stabilizing the blood-brain barrier, and improving neural connectivity. A key pathway is Keap1-Nrf2-ARE activation, which boosts mitochondrial antioxidant defences and limits oxidative DNA and protein damage. HXT also dampens brain inflammation by reducing microglial cytokine release and suppressing NF-κB/MAPK and NLRP3 inflammasome signalling—mechanisms implicated in Parkinson’s disease.❞
Translating from sciencese:
The cited human trials link HXT or HXT-rich olive oils to better vascular function, reduced inflammation, and improved cerebral blood flow. That’s correlation, though. In terms of causality, what’s been established is that daily intakes around 7–15 mg improve endothelial cell health, while single doses of 30–60 mg improve protection against free radicals.
Furthermore, HXT-rich olive extracts have been shown to improve memory, psychomotor speed, and attention–memory coupling in older adults, and supported mitochondrial health.
And where it mentioned Parkinson’s disease, that bit is because HXT is structurally identical to the dopamine metabolite DOPET, and thus helps regulate healthy dopamine levels.
You can read about this in full, here: Novel Ingredients: Hydroxytyrosol as a Neuroprotective Agent; What Is New on the Horizon?
Protection against stroke?
This is the part that’s not yet proven, but looks very promising.
Hydroxytyrosol might help protect against stroke, due to how it protects the brain’s blood vessels, most notably:
- Boosting the body’s natural antioxidant defences through the aforementioned Nrf2 pathway, helping arteries stay flexible and resilient under stress
- Keeping blood vessels healthy by preserving nitric oxide, which is vital for supporting healthy blood flow, and prevents the buildup of damaging plaque
- Dialing down overactive immune responses in blood vessel walls, reducing the slow-burning inflammation that often leads to stroke
In fewer words: hydroxytyrosol acts like a molecular shield—keeping the brain’s circulation strong, stable, and better protected against both blockages and bleeds.
For how all this ties together, see also the closely related: What’s Your Vascular Dementia Risk? ← includes actual numbers and a risk calculator tool and things like that
Want to learn more?
Check out:
- Black Olives vs Green Olives – Which is Healthier?
- All About Olive Oil (And: Is “Extra Virgin” Worth It?)
- Olive oil is healthy. Turns out olive leaf extract may be good for us too
Enjoy!
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Blueberries vs Redcurrants – Which is Healthier?
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Our Verdict
When comparing blueberries to redcurrants, we picked the redcurrants.
Why?
Both are great! But…
In terms of macros, blueberries have more carbs while redcurrants have nearly 2x more fiber as well as more protein; most of the numbers are small, but by virtue of the greater fiber, redcurrants win this round.
In the category of vitamins, blueberries have more of vitamins A, B3, B5, E, and K, while redcurrants have more of vitamins B1, B2, B6, B7, B9, and C, for a marginal win in this round.
Looking at minerals, blueberries have a little more manganese, while redcurrants have a lot more calcium, copper, iron, magnesium, phosphorus, potassium, selenium, and zinc, winning this round easily.
In other considerations, both are excellent sources of polyphenols, and the numbers (and variety) are close enough that this one will be decided by individual variation from one crop to the next. So in the interest of fairness, we’ll call this round a tie.
Adding up the sections makes for a clear overall win for redcurrants, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
21 Most Beneficial Polyphenols & What Foods Have Them
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Sweet Potato vs Winter Squash – Which is Healthier?
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Our Verdict
When comparing sweet potato to winter squash, we picked the sweet potato.
Why?
In terms of macros, the sweet potato has 2x the protein, 2x the carbs, and slightly more fiber. Because the protein numbers are small, the carb:fiber ratio is the deciding factor here, and has winter squash has the lower glycemic index (assuming cooking them both on a like-for-like basis), we’re going with that on macros, but it’s subjective.
In the category of vitamins, sweet potato has more of vitamins A, B1, B2, B3, B5, B6, C, E, and choline, while winter squash has more of vitamins B9 and K. It’s interesting to note that while sweet potato is rightly famous for its vitamin A content, winter squash is actually very good for that too. Still, by the numbers, it’s a clear 9:2 victory for sweet potato here.
When it comes to minerals, sweet potato has more calcium copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while winter squash has more selenium, meaning an 8:1 victory for sweet potato this time.
In short, enjoy either or both, but sweet potato is the more nutritionally dense option for sure.
Want to learn more?
You might like to read:
Carb-Strong or Carb-Wrong? Should You Go Light Or Heavy On Carbs?
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