Mosquitoes can spread the flesh-eating Buruli ulcer. Here’s how you can protect yourself

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Each year, more and more Victorians become sick with a flesh-eating bacteria known as Buruli ulcer. Last year, 363 people presented with the infection, the highest number since 2004.

But it has been unclear exactly how it spreads, until now. New research shows mosquitoes are infected from biting possums that carry the bacteria. Mozzies spread it to humans through their bite.

What is Buruli ulcer?

Buruli ulcer, also known as Bairnsdale ulcer, is a skin infection caused by the bacterium Mycobacterium ulcerans.

It starts off like a small mosquito bite and over many months, slowly develops into an ulcer, with extensive destruction of the underlying tissue.

While often painless initially, the infection can become very serious. If left untreated, the ulcer can continue to enlarge. This is where it gets its “flesh-eating” name.

Thankfully, it’s treatable. A six to eight week course of specific antibiotics is an effective treatment, sometimes supported with surgery to remove the infected tissue.

Where can you catch it?

The World Health Organization considers Buruli ulcer a neglected tropical skin disease. Cases have been reported across 33 countries, primarily in west and central Africa.

However, since the early 2000s, Buruli ulcer has also been increasingly recorded in coastal Victoria, including suburbs around Melbourne and Geelong.

Scientists have long known Australian native possums were partly responsible for its spread, and suspected mosquitoes also played a role in the increase in cases. New research confirms this.

Our efforts to ‘beat Buruli’

Confirming the role of insects in outbreaks of an infectious disease is achieved by building up corroborating, independent evidence.

In this new research, published in Nature Microbiology, the team (including co-authors Tim Stinear, Stacey Lynch and Peter Mee) conducted extensive surveys across a 350 km² area of Victoria.

We collected mosquitoes and analysed the specimens to determine whether they were carrying the pathogen, and links to infected possums and people. It was like contact tracing for mosquitoes.

Dead mosquito specimen in museum collection
Aedes notoscriptus was the mosquito identified as carrying the bacteria that caused Buruli ulcer.
Cameron Webb (NSW Health Pathology)

Molecular testing of the mosquito specimens showed that of the two most abundant mosquito species, only Aedes notoscriptus (a widespread species commonly known as the Australian backyard mosquito) was positive for Mycobacterium ulcerans.

We then used genomic tests to show the bacteria found on these mosquitoes matched the bacteria in possum poo and humans with Buruli ulcer.

We further analysed mosquito specimens that contained blood to show Aedes notoscriptus was feeding on both possums and humans.

To then link everything together, geospatial analysis revealed the areas where human Buruli ulcer cases occur overlap with areas where both mosquitoes and possums that harbour Mycobacterium ulcerans are active.

Stop its spread by stopping mozzies breeding

The mosquito in this study primarily responsible for the bacteria’s spread is Aedes notoscriptus, a mosquito that lays its eggs around water in containers in backyard habitats.

Controlling “backyard” mosquitoes is a critical part of reducing the risk of many global mosquito-borne disease, especially dengue and now Buruli ulcer.

You can reduce places where water collects after rainfall, such as potted plant saucers, blocked gutters and drains, unscreened rainwater tanks, and a wide range of plastic buckets and other containers. These should all be either emptied at least weekly or, better yet, thrown away or placed under cover.

A watering can sitting in garden and filled with water
Mosquitoes can lay eggs in a wide range of water-filled items in the backyard.
Cameron Webb (NSW Health Pathology)

There is a role for insecticides too. While residual insecticides applied to surfaces around the house and garden will reduce mosquito populations, they can also impact other, beneficial, insects. Judicious use of such sprays is recommended. But there are ecological safe insecticides that can be applied to water-filled containers (such as ornamental ponds, fountains, stormwater pits and so on).

Recent research also indicates new mosquito-control approaches that use mosquitoes themselves to spread insecticides may soon be available.

How to protect yourself from bites

The first line of defence will remain personal protection measures against mosquito bites.

Covering up with loose fitted long sleeved shirts, long pants, and covered shoes will provide physical protection from mosquitoes.

Applying topical insect repellent to all exposed areas of skin has been proven to provide safe and effective protection from mosquito bites. Repellents should include diethytolumide (DEET), picaridin or oil of lemon eucalyptus.

While the rise in Buruli ulcer is a significant health concern, so too are many other mosquito-borne diseases. The steps to avoid mosquito bites and exposure to Mycobacteriam ulcerans will also protect against viruses such as Ross River, Barmah Forest, Japanese encephalitis, and Murray Valley encephalitis.The Conversation

Cameron Webb, Clinical Associate Professor and Principal Hospital Scientist, University of Sydney; Peter Mee, Adjunct Associate Lecturer, School of Applied Systems Biology, La Trobe University; Stacey Lynch, Team Leader- Mammalian infection disease research, CSIRO, and Tim Stinear, Professor of Microbiology, The University of Melbourne

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Bath vs Shower – Which is Healthier?

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    Our Verdict

    When comparing bathing to showering, we picked the shower.

    Why?

    For the basic task of getting your body clean, the shower is better as it is an entirely one-way process. Clean water hits your body, dirty water leaves it, and no dirt is making its way back.

    Baths do not have this advantage, and if you enter a bath dirty, you will then be sitting in dirty water. You will leave it a lot cleaner than you entered it (because a lot of the dirt stayed in the bathwater to be drained away after the bath), but not as clean as if you had showered.

    One could argue soap or equivalent will prevent the dirt re-sticking, and that’s true, but it’s true for soap in the shower too, so it doesn’t offset anything.

    Additionally, being immersed in water for more than 15 minutes can start to have a (paradoxically) dehydrating effect on the skin; this happens not only because of losing skin oils to the water, but also because of osmosis, the resultant mild edema, the body’s homeostatic response to the mild edema, then getting out the bath and drying, leaving one with the response having now just caused dehydrated skin.

    Baths do have some health advantages! And these come primarily from the mental health benefits of relaxation in warm water and/or generally pampering oneself. Additionally, some bath oils or bath salts can be beneficial in a way that couldn’t be administered the same way in the shower.

    Best of both worlds?

    In some parts of the world (Thailand and Turkey come to mind; doubtlessly there are many others) there are traditions of first taking a shower to get clean, and then taking a bath for the rest of the bathing experience. As a bonus, the bathing experience is then all the more pleasant for the water remaining just as clean as it was to start with.

    However, if you do have to pick one (and for the purpose of our “This or That” exercise, we do), then it’s the shower, hands-down.

    Want to read more?

    You might want to also take into account how it’s still possible to have too much of a good thing:

    Enjoy!

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  • Cannabis Myths vs Reality

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Cannabis Myths vs Reality

    We asked you for your (health-related) opinion on cannabis use—specifically, the kind with psychoactive THC, not just CBD. We got the above-pictured, below-described, spread of responses:

    • A little over a third of you voted for “It’s a great way to relax, without most of the dangers of alcohol”.
    • A little under a third of you voted for “It may have some medical uses, but recreational use is best avoided”.
    • About a quarter of you voted for “The negative health effects outweigh the possible benefits”
    • Three of you voted for “It is the gateway to a life of drug-induced stupor and potentially worse”

    So, what does the science say?

    A quick legal note first: we’re a health science publication, and are writing from that perspective. We do not know your location, much less your local laws and regulations, and so cannot comment on such. Please check your own local laws and regulations in that regard.

    Cannabis use can cause serious health problems: True or False?

    True. Whether the risks outweigh the benefits is a personal and subjective matter (for example, a person using it to mitigate the pain of late stage cancer is probably unconcerned with many other potential risks), but what’s objectively true is that it can cause serious health problems.

    One subscriber who voted for “The negative health effects outweigh the possible benefits” wrote:

    ❝At a bare minimum, you are ingesting SMOKE into your lungs!! Everyone SEEMS TO BE against smoking cigarettes, but cannabis smoking is OK?? Lung cancer comes in many forms.❞

    Of course, that is assuming smoking cannabis, and not consuming it as an edible. But, what does the science say on smoking it, and lung cancer?

    There’s a lot less research about this when it comes to cannabis, compared to tobacco. But, there is some:

    ❝Results from our pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long-term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.❞

    Read: Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium

    Another study agreed there appears to be no association with lung cancer, but that there are other lung diseases to consider, such as bronchitis and COPD:

    ❝Smoking cannabis is associated with symptoms of chronic bronchitis, and there may be a modest association with the development of chronic obstructive pulmonary disease. Current evidence does not suggest an association with lung cancer.❞

    Read: Cannabis Use, Lung Cancer, and Related Issues

    Cannabis edibles are much safer than smoking cannabis: True or False?

    Broadly True, with an important caveat.

    One subscriber who selected “It may have some medical uses, but recreational use is best avoided”, wrote:

    ❝I’ve been taking cannabis gummies for fibromyalgia. I don’t know if they’re helping but they’re not doing any harm. You cannot overdose you don’t become addicted.❞

    Firstly, of course consuming edibles (rather than inhaling cannabis) eliminates the smoke-related risk factors we discussed above. However, other risks remain, including the much greater ease of accidentally overdosing.

    ❝Visits attributable to inhaled cannabis are more frequent than those attributable to edible cannabis, although the latter is associated with more acute psychiatric visits and more ED visits than expected.❞

    Note: that “more frequent” for inhaled cannabis, is because more people inhale it than eat it. If we adjust the numbers to control for how much less often people eat it, suddenly we see that the numbers of hospital admissions are disproportionately high for edibles, compared to inhaled cannabis.

    Or, as the study author put it:

    ❝There are more adverse drug events associated on a milligram per milligram basis of THC when it comes in form of edibles versus an inhaled cannabis. If 1,000 people smoked pot and 1,000 people at the same dose in an edible, then more people would have more adverse drug events from edible cannabis.❞

    See the numbers: Acute Illness Associated With Cannabis Use, by Route of Exposure

    Why does this happen?

    • It’s often because edibles take longer to take effect, so someone thinks “this isn’t very strong” and has more.
    • It’s also sometimes because someone errantly eats someone else’s edibles, not realising what they are.
    • It’s sometimes a combination of the above problems: a person who is now high, may simply forget and/or make a bad decision when it comes to eating more.

    On the other hand, that doesn’t mean inhaling it is necessarily safer. As well as the pulmonary issues we discussed previously, inhaling cannabis has a higher risk of cannabinoid hyperemesis syndrome (and the resultant cyclic vomiting that’s difficult to treat).

    You can read about this fascinating condition that’s sometimes informally called “scromiting”, a portmanteau of screaming and vomiting:

    Cannabinoid Hyperemesis Syndrome

    You can’t get addicted to cannabis: True or False?

    False. However, it is fair to say that the likelihood of developing a substance abuse disorder is lower than for alcohol, and much lower than for nicotine.

    See: Prevalence of Marijuana Use Disorders in the United States Between 2001–2002 and 2012–2013

    If you prefer just the stats without the science, here’s the CDC’s rendering of that:

    Addiction (Marijuana or Cannabis Use Disorder)

    However, there is an interesting complicating factor, which is age. One is 4–7 times more likely to develop a substance abuse disorder, if one starts use as an adolescent, rather than later in life:

    See: Likelihood of developing an alcohol and cannabis use disorder during youth: Association with recent use and age

    Cannabis is the gateway to use of more dangerous drugs: True or False?

    False, generally speaking. Of course, for any population there will be some outliers, but there appears to be no meaningful causal relation between cannabis use and other substance use:

    Is marijuana really a gateway drug? A nationally representative test of the marijuana gateway hypothesis using a propensity score matching design

    Interestingly, the strongest association (where any existed at all) was between cannabis use and opioid use. However, rather than this being a matter of cannabis use being a gateway to opioid use, it seems more likely that this is a matter of people looking to both for the same purpose: pain relief.

    As a result, growing accessibility of cannabis may actually reduce opioid problems:

    Some final words…

    Cannabis is a complex drug with complex mechanisms and complex health considerations, and research is mostly quite young, due to its historic illegality seriously cramping science by reducing sample sizes to negligible. Simply put, there’s a lot we still don’t know.

    Also, we covered some important topics today, but there were others we didn’t have time to cover, such as the other potential psychological benefits—and risks. Likely we’ll revisit those another day.

    Lastly, while we’ve covered a bunch of risks today, those of you who said it has fewer and lesser risks than alcohol are quite right—the only reason we couldn’t focus on that more, is because to talk about all the risks of alcohol would make this feature many times longer!

    Meanwhile, whether you partake or not, stay safe and stay well.

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  • Ice Baths: To Dip Or Not To Dip?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We asked you for your (health-related) view of ice baths, and got the above-depicted, below-described, set of responses:

    • About 31% said “ice baths are great for the health; we should take them”
    • About 29% said “ice baths’ risks outweigh their few benefits”
    • About 26% said “ice baths’ benefits outweigh their few risks”
    • About 14% said “ice baths are dangerous and can kill you; best avoided”

    So what does the science say?

    Freezing water is very dangerous: True or False?

    True! Water close to freezing point is indeed very dangerous, and can most certainly kill you.

    Fun fact, though: many such people are still saveable with timely medical intervention, in part because the same hypothermia that is killing them also slows down the process* of death

    Source (and science) for both parts of that:

    Cold water immersion: sudden death and prolonged survival

    *and biologically speaking, death is a process, not an event, by the way. But we don’t have room for that today!

    (unless you die in some sudden violent way, such as a powerful explosion that destroys your brain instantly; then it’s an event)

    Ice baths are thus also very dangerous: True or False?

    False! Assuming that they are undertaken responsibly and you have no chronic diseases that make it more dangerous for you.

    What does “undertaken responsibly” mean?

    Firstly, the temperature should not be near freezing. It should be 10–15℃, which for Americans is 50–59℉.

    You can get a bath thermometer to check this, by the way. Here’s an example product on Amazon.

    Secondly, your ice bath should last no more than 10–15 minutes. This is not a place to go to sleep.

    What chronic diseases would make it dangerous?

    Do check with your doctor if you have any doubts, as no list we make can be exhaustive and we don’t know your personal medical history, but the main culprits are:

    • Cardiovascular disease
    • Hypertension
    • Diabetes (any type)

    The first two are for heart attack risk; the latter is because diabetes can affect core temperature regulation.

    Ice baths are good for the heart: True or False?

    True or False depending on how they’re done, and your health before starting.

    For most people, undertaking ice baths responsibly, repeated ice bath use causes the cardiovascular system to adapt to better maintain homeostasis when subjected to thermal shock (i.e. sudden rapid changes in temperature).

    For example: Respiratory and cardiovascular responses to cold stress following repeated cold water immersion

    And because that was a small study, here’s a big research review with a lot of data; just scroll to where it has the heading“Specific thermoregulative adaptations to regular exposure to cold air and/or cold water exposure“ for many examples and much discussion:

    Health effects of voluntary exposure to cold water: a continuing subject of debate

    Ice baths are good against inflammation: True or False?

    True! Here’s one example:

    Winter-swimming as a building-up body resistance factor inducing adaptive changes in the oxidant/antioxidant status

    Uric acid and glutathione levels (important markers of chronic inflammation) are also significantly affected:

    Uric acid and glutathione levels during short-term whole body cold exposure

    Want to know more?

    That’s all we have room for today, but check out our previous “Expert Insights” main feature looking at Wim Hof’s work in cryotherapy:

    A Cold Shower A Day Keeps The Doctor Away?

    Enjoy!

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  • To-Do List Formula – by Damon Zahariades

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    The first part of this book is given to reviewing popular to-do list methods that are already widely “out there”. This treatment is practical and exploratory, looking at the pros and cons of each.

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    You may be wondering what you, dear reader, can expect to get out of this book. Well, that depends on where you’re coming from:

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    All in all, a very respectable book for anyone’s to-read list!

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  • The Gut-Healthiest Yogurt

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    Not only is this yogurt, so it’s winning from the start with its probiotic goodness, but also it’s full of several kinds of fiber, and gut-healthy polyphenols too. Plus, it’s delicious. The perfect breakfast, but don’t let us stop you from enjoying it at any time of day!

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    (we suggest you read everything at least once before doing anything)

    1) Soak the dried figs, the dates, and half the seeds in hot water for at least 5 minutes. Drain (be careful not to lose the chia seeds) and put in a blender with ¼ cup cold water.

    2) Blend the ingredients from the last step into a purée (you can add a little more cold water if it needs it).

    3) Mix this purée into the yogurt in a bowl, and add in the remaining seeds, mixing them in thoroughly.

    4) Top with the sliced figs, and serve (or refrigerate, up to a few days, until needed).

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  • No Time to Panic – by Matt Gutman

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    Matt Gutman is not a doctor or a psychologist. He’s a journalist, accustomed to asking questions and then asking more probing questions, unrelenting until he gets the answers he’s looking for.

    This book is the result of what happened when he needed to overcome his own anxiety and panic attacks, and went on an incisive investigative journey.

    The style is as clear and accessible as you’d expect of a journalist, and presents a very human exploration, nonetheless organized in a way that will be useful to the reader.

    It’s said that “experience is a great teacher, but she sends hefty bills”. In this case as in many, it’s good to learn from someone else’s experience!

    By the end of the book, you’ll have a good grounding in most approaches to dealing with anxiety and panic attacks, and an idea of efficacy/applicability, and what to expect.

    Bottom line: without claiming any magic bullet, this book presents six key strategies that Gutman found to work, along with his experiences of what didn’t. Valuable reading if you want to curb your own anxiety, or want to be able to help/support someone else with theirs.

    Click here to check out No Time To Panic, and find the peace you deserve!

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